Before the film's release, the pairing of Santos and de Guzman was proven to be successful for audiences.  Paano Ang Puso Ko? marked the sixth time (including minor roles) they had partnered in a film after the success of their first team-up in ABS-CBN 's longest teleserye , Mara Clara .   In addition, de Guzman was already popular during that time as a performer of Universal Motion Dancers (UMD), a dancing group in the Philippines.  It also marks Yan's first film role with Santos  after working together in the teen drama series Gimik .  Nevertheless, their combination was also popular during that time.  The film was a box-office success.